GSK2983559 free acid

Research use only, not for human use.

GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2).

GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammatory bowel disease explant samples.

GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells. Cell Viability Assay Cell Line:THP-1 cells Concentration:1-1024 nM Incubation Time:2 hours Result:Inhibited IL-8 production with an IC50 of 1.34 nM.

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse. Animal Model:C57BL/6 mice (female) injected with MDP (100 μg) Dosage:3 and 10 mg/kg Administration:Oral gavage; 3 and 10 mg/kg; once Result:Suppressed serum IL-6 levels in a dose-dependent manner.

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Others

Other Targets

leucyl-tRNA synthetase| Ras-related GTP-binding protein D (RagD)

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1579965-12-0

538.53

C21H23N4O7PS2

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (9.28 mM)

CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCOP(O)(O)=O

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(-20℃)

With Ice Pack

≥ 2 years